Tag Archives: IVF

Covid Vaccine Infertility? Results of first human study revealed

Although there is a lot of technical evidence that the Covid vaccine is safe and effective, there are still some people who are uneasy about vaccination. In addition, some people want to prevent others from get a mixed vaccine by lying, spreading misinformation, or misrepresenting known actualities. As a answer, fertility professionals around the world have been asking ladies questions, and they heard that mingled inoculations may oblige them permanently sterile. Today, I will release the results of the original research conducted by InfertilityTV on IVF1 on the impact of Covid and Covid vaccination on female fertility. To understand this research, I genuinely need to discuss the misinformation distribute on social media and some background information about co-vaccine and infertility. If you want to skip to the research results, just click on the “Research Results” chapter in the specific characteristics. This study was conducted at my IVF1 clinic at the Naperville Fertility Center in the United Nation. The experiment has been carried out from January 2021 until now. During this period, two Covid vaccines are available. BioNTech/ Pfizer’s vaccine and Moderna’s inoculation. Both are RNA vaccines. This means that we are not injecting viruses or parts of viruses into parties, but introducing small-time molecules of RNA into parties. RNA apprises some of your cells to call the parts of the virus as Spike proteins. The spike protein allows the virus to enter your cell. When your body spots this foreign protein, it will begin to produce antibodies against it. Some of these antibodies against spike proteins thwart the virus from participating your cells. These are called counterbalancing antibodies. Neutralizing antibodies protect us from illnes. Without your knowledge, we will go to restaurants and movie theater again. Will the process of vaccination and antibody constitution make permanent infertility in wives? First, a little background…After fertilization, the fetu begins to divide. After 5-6 periods, the normally developing embryo will be divided into more than one hundred cells, called blastocysts. The blastocyst has two types of cadres. A group of cells, called the inner cell mass, continues to form the fetus. The so-called nourishment of a larger population of cells goes on to form the placenta. When the blastocyst embryo embed, the trophoblast cadres burrow into the inner wall of the uterus. This process will be required certain trophoblast cadres continue to divide and some of them fuse together. Cells that save fractioning are called trophoblasts. The fused together are called syncytial trophoblast cadres. Both categories are essential for normal placental operate. There is a protein in these placental cadres called syncytin-1. Studies have shown that syncytin-1 is essential in the formation of syncytrotrophoblast cells and is also responsible for establishing blood circulation from the mother to the placenta. This allows oxygen and nutrients to be delivered to the fetus. The biggest concern caused by misinformation about symbiotic vaccines is that they may cause infertility by instructing the immune method to incorrectly attack syncytin-1, which frustrates embryos from implanting in the uterus. This will be very worrying, because once the immune arrangement is ready to recognize and destroy it, it will be difficult or impossible to stop it. Every time an embryo tries to implant for the rest of a woman’s life, her immune plan will affect and prevent it from implanting, ensuing in permanent infertility. Does this make sense? A statement? No. First, this theory relies on the structural affinity of the spike protein of syncytial-1. Which is not. Proteins are consisting of representatives of specific amino acid cycles. Syncitin-1 is 538 amino battery-acids long. The spike protein of SARS CoV-2 is 9,860 amino battery-acids long. This means that the spike protein is more than 18 times larger than Synthin 1. It’s like conflating elephants with puppies. More importantly, the longest similar amino battery-acid string between two proteins is 4 amino acids long. The similar quantity is far too low to muddle your immune method. Second, from the Yale University School of Medicine, the first team, led by immunologist Akiko Iwasaki, watched the response of 3000 different proteins worded in the human body. Result antibody natural covid infection or covid vaccination. They did not respond to syncytin-1. This meant that antibodies from covid illnes or covid inoculation will not cause confusion and will not attack syncytin-1. Third, the company that produces the inoculation has also conducted animal safety studies. In the data they reported to the US FDA, when animals were vaccinated before copulating and during pregnancy, they did not find any adverse effects on female reproduction or fetal or fetu growth. Okay, we have laboratory research and animal investigate, but there hasn’t been any clinical investigate to study the impact of vaccines on human women…until now. Our research is aimed at gals trying IVF. Currently, top-level IVF procedures frequently play-act IVF in two theatres. In the earliest stages, embryos are created in the IVF laboratory and then frozen. In the second stage, the embryo is thawed and placed in the patient’s developed uterus. This is called frozen embryo transfer or FET. The utilization of frozen embryo move is an excellent model for studying the effects of various factors on implantation, because it bypass numerous variables that usually alter a woman’s ability to become pregnant, such as ovulation, fertilization, and early embryo proliferation. With FETs, we know that every woman studied has a well-developed embryo in the uterus.Our study investigated whether there is any difference in gestation rates between women who received the Covid vaccine and women who did not receive the Covid vaccine. We are also welcome to look at the impact of previous Covid infections. The labouring principle of this research is as follows. At the beginning of each treatment, all our FET patients undergo baseline blood tests and ultrasound interrogations. One of the blood tests we started in January was to look for Covid antibodies in the blood. For this, we exploited the Elecsys Anti-SARS-CoV-2 analysis method of Roche Diagnostics. This is a highly selective test that simply recognizes antibodies against spike proteins. These antibodies may come from vaccinations or previous infections, so when we find that a patient has Covid antibodies, we communicate with them to be informed about if they have received one of the inoculations or if they are infected with Covid or have a positive nasal swab for Covid. past. Those women who have not been injected or have a previously known disease are presumed to have a previous asymptomatic illnes. A blood assessment can determine the occurrence of pregnancy. Embryonic trophoblast cells produce the hormone hCG. After the embryo embeds and supports contact with the mother’s blood supply, the mother can be tested for hCG through blood tests. Since implantation occurs two to three days after the fetu is placed in the uterus, our patient returned for blood tests eight dates after the fetu transpose. A positive result indicates that the embryo’s trophoblast cells can create hCG, implant in the endometrium and continue to develop, enough to establish contact with the mother’s blood circulation.The last-place two steps depend on the syncytin 1 protein. If the mother’s immune arrangement criticizes the syncytin-1 protein and thus expenses or destroys the placenta, then she is not is pregnant, and therefore the hCG pregnancy test is negative. The pregnancy charge is calculated by dividing the number of women undergoing a positive experiment by the total number of women undergoing embryo transfer. So what do our results evidence? There is no statistical divergence in pregnancy paces between women who have received the vaccine and those who have not been vaccinated. Nearly 70% to 75% of women undergoing embryo transfer are pregnant. By the mode, these compass are announced confidence intervals. This is a statistical implement. They told us that we can be 95% sure that the true pregnancy rate is within this range-just in case our gestation charge may be wrung by the low-grade count. Since the arrays of the groups overlap, we can be sure that there is no difference between the groups.What about women who have acquired antibodies due to previous COVID-1 9 infections? Points have proved that their pregnancy rates are also in the same range as inoculated women and women without antibodies. Eventually, because Roche analysis provided us with numerical antibody heights, we compared those women with the highest antibody titers with those without antibodies, but still attained no difference in maternity rates. After a positive maternity assessment, some gals may continue to miscarry. Next, we want to see if the immune organization is detrimental the placenta after fetu implantation. If a woman has a positive gestation exam decision, we will make her to the early maternity for an ultrasound in a few weeks.With a viable pregnancy, we firstly want to see the fluid-filled sac in the uterus. After about a week, we want the early developing fetus tremble in the tube and eventually become the heart. We found that there was no difference in the abortion rate after the blood exam until the first ultrasound or between the first and second ultrasound. The bottom line of our InfertilityTV is this. “Were not receiving” biologically rational reason to believe that the Covid vaccine will motive female infertility. Laboratory research, animal research, and current real-world human research all refute the idea that mixed inoculations cause infertility. Our data does not support the increased risk of failure. Therefore, please roll up your sleeves and purchase the vaccine as soon as possible. I truly want to see Marvels Black Widow in a real movie theater. Hopefully we can finally find out how Natasha Rominoff was forcibly disinfected during her training to become a master assassin. At least we know that they should not use a mixed vaccine ..

IVF success: How good is the 2nd (or 3rd) embryo transfer?

I have been getting some interesting questionslately about IVF pregnancy proportions such as Ive heard that parties never is pregnant on the firsttry, is that right? or Is the success rates for IVF higher on the second try Does the uterusneed a few practice runs before a pregnancy can happen? Today, on InfertilityTV, I will discusswhat the science says about these questions. In require to have a discussion about pregnancyrates, we must first make sure that we are all talking about the same concepts. Gives say1 00 marries have gone through an egg retrieval and each duo has three embryos frozen. Those1 00 duos then start their frozen embryo transfer preparation. A single embryo is thawedand carried for each duo. For this lesson, we will assume that 100% of the embryos survivethe thawing process. This isnt always the case, however. During the first embryo transport struggle, sixty pairs become pregnant. That is a pregnancy rate of 60%. This leaves 40 duos who didnot become pregnant. Those 40 marries then go through a second embryo transfer and 24 of thecouples become pregnant.For this second attempt, the gestation proportion is again 60%. No difference.The maternity charge in the first and second attempt was the same. IVF doctors said here today that thepregnancy PER TRANSFER is the same. However, you can also calculate the total number of coupleswho became pregnant over both assaults. Sixty marries is pregnant on the 1st assault and2 4 couples is pregnant on the second attempt. The total is 84. IVF doctors will say that thecumulative gestation charge over two assaults is 84%. This is a very important point. The pregnancyrate on each endeavor was the same – 60% – but the cumulative pace over two cycles was 84%. People often get this confounded and erroneously argued that the maternity charge on the secondattempt ONLY is 84% – but this is not correct. With that background, what do the numbers look like where Iwork at the Naperville Fertility Center. So far this year, I have played 300 frozen fetu carries. 217 of those we play-act on patients doing their 1st, 2nd or 3rdattempt. Eight epoches after the fetu carry, we play a blood test to look at their hCG level. Apatient was diagnosed as pregnant if their hCG was greater than 5 and then increased twoto three days later.Since we know that gestation rates decline in older dames, we segmented individual patients into three radicals. Group 1 were transportations in which we utilized embryosthat were tested for chromosome abnormalities. This is known as PGT. The opportunity for pregnancywith experimented fetus does not differ by age – one we know the embryo is normal, older and youngerpatients have the same chance for gestation .. Radicals two and 3 were transports withuntested fetus in younger and older ladies. Now are the pregnancy charges for measured embryos.As you can see, the maternity frequencies were roughly the same whether it was the first, secondor third endeavor. For younger patients with untested embryos, again there was no difference inthe chance for pregnancy through three struggles. For older patients, the pregnancyrate was the same through two struggles and weakened a bit on the third attempt.So gives go back to those questions thatI have been coming. Question 1 was Ive heard that people never get pregnant onthe first try, is that true? Clearly, that is not true. Pregnancy frequencies on the firstattempt were the same as with precede struggles. Question two was Is the success ratefor IVF higher on the second try? We have now shown that this is not the case.Question three was Does the uterus need a few practice runs before a pregnancy canhappen? Clearly, this is not true either.Lets look at one more question. If couplesdo a second transfer, it is either because their first struggled neglected – meaning they didntget pregnant or miscarried on the first attempt or they became pregnant and delivered andare now coming back for a second child. These are two very different situations. Itbrings up a few questions: Is the chance for pregnancy better if the first try resultedin a delivery? Looking at our data, I was not able to show that duos with a previously deliveryhad a better chance on their next fetu change Our InfertilityTV Bottom line is this.The pregnancy charges with frozen fetu deliveries don’t change much over threeattempts. On average, your chances for getting pregnant on your 1st try is similarto the chance on your second or third try.

How To Have Twins: Get the Truth from a Fertility Expert

Now at InfertilityTV, I get a lot of questionsfrom duets who are trying to have twins about opportunities of twinneds with fertilitytreatments. Much of what is out there is wrong so today I will separate the facts of the case from myth Most parties are familiar with the fact thatthere are basically two different types of twinneds. The first type are identical twins. Identicaltwins arise from a divide in the fetu shortly after fertilization. Now are some facts about identical twins Identical twins are extraordinary. Merely, about3- 4 of every 1000 births are identical twins.Identical twins even out about of all twinsWith a few rare objections, this doesn’t seem to vary much based on where you live or otherfactors Identical twins dont generally run in families, though there are some very rare categories where it might happen.These rare class point to the possibility that there may be genes that increase thechance for monozygous twin, though scientists have not yet been able to pin down any specificgenes yet. The fertility prescription Clomid is well knownto increase the chance for dizygotic twin but this 2006 study too found that the proportionof identical twins was higher when twins resulted with Clomid compared to a group of naturallyoccurring twinneds. The only well documented part that increasesthe risk of identical twin is IVF. Growing embryos in the laboratory seem to increasethe chance that human embryos will split.The longer they stay in the lab, the greater thechance. For fetu gives that are available after growingembryos for 2-3 days, identical twins occur about 1-2% of the timeWaiting until the blastocyst stage at 5 to 6 epoches increases the an opportunity to about 2-3% and making a hole in the husk bordering the fetu, known as “Assisted Hatching” approximately doubles the chance that the embryo will separate Fraternal twins are a lot more interesting.Fraternal twinneds arise from fertilization of two different eggs by two different sperm.There are several factors that seem to influence a woman having fraternal twins naturally, that is without the use of birthrate drugs. GeographySub Saharan Africa insures about 23 identical twin for every 1000 births.Asian countries have about 5 per 1000 deliveries. The US is in the middle with about 10 to 12 per 1000 deliveries that occur naturally Body typeTall women appeared to have one and a half to two times the chance for twinneds in somestudies but not in others Maidens with a BMI over 30 had a 62% higherchance of twins and women with a BMI less than 20 had a 38% lower luck for twins.Genetics. Fraternal twins do run in families. For agiven couple, if twinneds run in the females family, or if the woman herself is a twin, the couple has a higher chance for twins themselves. If twins run in the males clas, the coupledoesnt have a higher chance for twins but if the couple have daughters, they will havea higher chance for twinneds. The overall blow of family history may increase the chancefor a twin by 1 and a half to two times – so about 15 to 20 twins per 1000 gives. Age. It is the case that as wives get older, they havea higher chance of secreting more than one egg at the time of ovulation and so – theyhave a higher chance of a twinned pregnancy. The impact here is pretty strong. Women intheir late 30 s and early 40 s have about four times the chance for twinneds compared to womenin their late teens. The twin frequency in older gals is about 40 per 1000 deliveries What about menu? Yams – Some beings have formulated that the reason why some regions in Africa, like Nigeria, have a higher twin rate is because of the presence of yams in their diet.The evidencehere, nonetheless, is extremely weak. Dairy produces – One small study suggestedthat the milk from cows that received expansion hormone would have higher levels of a hormonecalled IGF-1 and that women who drank the milk from these kine would therefore havehigher IGF-1 positions themselves – which would in turn, stimulate the ovaries to produce multipleeggs. However, studies in women who drank a lot of milk saw no increase in their IGF-1levels. Dairy makes are unlikely to influence the chance for twinneds What about drugs? Metformin – Metformin is a medication that is used to induce ovulation in women withPCOS. Metformin does not increase the risk for twins.Folic acid – folic battery-acid or folate is a supplement that all women should take if they are planningto become pregnant since it reduces the risk of certain birth defects. The suggestion ismixed now – with some studies indicating a slight increase in twins and other studies findingno increase. At this place, the weight of evidence indicates against any effect.Letrozole – This medication is used to induce ovulation in women with PCOS. Studies havefound a twinned pace of 10% or higher or at least 100 twinneds per 1000 pregnanciesClomid or clomiphene citrate has about the same rate of twins as letrozoleInjectable fertility remedies like Follistim or Gonal F has a twinned rate of 25 to 30% anda jolly substantial charge of triplets and quadruplets With IVF,. the rate of identical twin dependsprimarily on the number of embryos transmitted. If two fetus are moved, in a worldclass IVF program like IVF1, the chance for twin pregnancy surpasses 60% If you liked this video, recollect to Likethis video. If you have an idea for a future episode of InfertilityTV, left open in thecomments. Subscribe now. InfertilityTV publishes a brand-new episode every week. Its like havinga fertility consultant in your telephone ..

IVF cost too high? Best IVF protocols & tips to reduce IVF cost w/o hurting IVF success

There is no doubt that IVF is the bestfertility treatment with the highest pregnancy rate. However, IVF is also themost expensive fertility treatment. There are lanes that you can reduce some IVF costs and make it more inexpensive stay adjusted. First, let’s talk about the differentcomponents that make up the cost for IVF You have IVF medications, checking, theIVF egg retrieval, the stuff that’s done in the laboratory and then the IVFtransfer. Let’s talk about IVF medications first. There are several different types of remedies used in the process of inducing the ovariesbefore the egg retrieval. The most expensive of these medications are called gonadotropins. These are the prescriptions that containthe hormones FSH or LH Some of the firebrands that are commonly used include: Follistim, Gonal-F and Menopur Both Follistim and Gonal-F contain FSH and serve as the primary hormone to stimulate the ovaries.Some doctors, however, like to add Menopur Menopur contains both FSH and LH.Doctors who like Menopur use it for the computed LH but this is an expensive select. Thedaily cost for an average 150 international legion dose of Menopur is $180 per date. Over the course of an average 10 days stimulant this addsnearly $2,000 to your drug payments. A less expensive alternative, which I useat the Naperville Fertility Center, is called the low-grade dose hCG protocol. hCG and LH are very similar hormones. You can use hCG in place of LH and it actually worksbetter because it lasts longer in the body. One firebrand of hCG announced Pregnyl payments about 110 dollars for one bottle But that one bottle will previous you for theentire stimulation. So this one change to your etiquette is not merely wields better, butcan save you about $1,700 in medication expenses by not having to use Menopur.Butwait – there’s more !!! hCG is roughly six times more potentthan FSH So formerly the FSH has started yourfollicles flourishing, and you start hCG, you can reduce the dose of FSH or in somecases stop it totally How much does this save you? If we use an average IVFdose of FSH of 300 international contingents per era A 600 international unitcartridge of Follistim would previous you two days and cost about six hundred andtwenty dollars Over a ten daylight foreplay, that’s about $3,100. But if you start low-grade dose hCG by am telling the sixth period and abbreviate the dose of FSH to 75 youwould save another $1,300 in medication payment If you’re individual patients who doesn’trespond well to birthrate remedy which fertility physicians call a poorresponder, this reform trying to save you various thousand dollars. Just think whatyou could do with all of that extra money How about the IVF laboratory? Doyou know that there are two different ways that eggs can be fertilized withsperm? In the first approach, sperm are placed in the lab dish near the egg.Thisis called standard insemination. The second procedure involves inserting a spermdirectly into an egg. This technique is announced ICSI, which stands forintracytoplasmic sperm injection. Most IVF middles will blame an additional $ 1200 to $2000 dollars to do ICSI. So should be used pay the extraamount? If you’re a duet with a male factor, like low-toned seman tallies, poormotility or an abnormal Cap-Score or a history of failed fertilization, then youshould perfectly invest the money to have ICSI. But what if you aren’t inone of these groups? First, it’s important to understand that maternity frequencies withICSI are not any better than with standard insemination.ICSI is just a toolto get the eggs manured. If you have a ordinary semen analysis and Cap-Score and “youre using” standard insemination, the risk that none of the eggs will manure issomewhere around 5 to 15%. In other words, there is a 5 to 15% likelihood youcould end up with zero embryos. If that risk is acceptable to you, then youshould discuss standard insemination with medical doctors. What would really begreat is if you had medical guarantee that plastered the cost of IVF.Here in theUnited States, there are various states that require insurance coverage for IVF.The best two states for IVF coverage are Illinois, where the Naperville FertilityCenter is located, and Massachusetts. All over the world, there are somecountries that pay for IVF as part of their national health services, like theU.K. But there are often restraints. In Ontario, Canada, for example, you can get one cycle of IVF paid for, but you are still responsible for the medicationcosts. So my gratuities would be very helpful to our close friends to the north. If youlike this video remember to like this video. If you have an idea for a futureepisode of InfertilityTV, left open in the comments.Subscribe now! InfertilityTV liberates a brand-new episode every week. It’s like having a fertilityspecialist in your phone.

Fertility expert tips: How to double your Clomid pregnancy rate

Clomid combined with IUI is a commonmethod used by fertility experts to improve the chances for pregnancy incouples with unexplained infertility. We know that clomid can improve the chance forpregnancy by increasing the number of eggs the hell is exhausted and IUI can increase the chancefor pregnancy by increasing the number of sperm that contact the fallopian tubes. IUIrequires precise duration, however. The best pregnancy paces are displayed when theinsemination is done on the day of ovulation. One of the ways in which doctors willmonitor clomid cycles is with blood tests and ultrasound. Eggs are located inside tinycysts called follicles. As an egg grows, the follicle thrives larger.This can be seenand evaluated on ultrasound. When a medical doctor recollects the eggs are mature, the eggs canbe exhausted from the ovary with a one time injection of a medication called hCG.This is known as triggering ovulation. This is a very accurate way todetermine the timing for IUI since we know that ovulation comes about 36 hoursafter a woman receives the trigger injection. What is the best time to trigger ovulation? Shouldit be done when the follicles are smaller? Some doctors think this is best. They worry thatthe quality of the eggs from large follicles might be settlement by waiting too long. Otherdoctors worry that by triggering ovulation earlier might result in the secrete of immatureeggs that won’t be able to be fertilized. Recently, research studies was done thathelps us answer this question. Doctors looked at about 1700 Clomid cyclesthat had ovulation provoked with hCG and pregnancy was attempted with IUI.Theycompared the gestation proportions based on how big-hearted the largest follicle measuredon ultrasound when hCG was given. The pregnant and non pregnant groups wereotherwise very similar. What did the results register? When the largest follicle measuredbetween 17 and 20 mm, the gestation pace was about 8 %. Between 20 and 21 mm, the gestation rate was about 11%. However, when the largest follicle was over2 1 mm, the gestation frequency was about 16%! It isnt always possible to get afollicle that large-hearted, however. Sometimes, a womans body will prompt ovulation on itsown when the follicle is smaller. Other epoches, the follicles reach a plateau oreven start to decrease in size. This does not mean that other factors dontimpact the chance for IVF success.A womans age, load, infertility diagnosis andher collaborators sperm figures can also affect Clomid pregnancy frequencies. However, all other things being equal, larger folliclesproduce more maternities than smaller ones ..